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Best NMN Supplement: Top 5 NMN Brands In 2023

This is sponsored content. M&F is not endorsing the websites or products listed in this article.

Aging is one of life’s unfortunate, but inevitable facts: we might be able to disguise the wrinkles for a time, but we will all start to feel the effects of aging sooner or later.

Longevity scientists have been searching for molecules that could potentially extend our healthspan (the number of years we remain in good health). And NMN supplements are touted as one of the most promising agents to support healthy aging.

Taking NMN supplements boosts NAD+ levels which has been shown to have potent health benefits in animal studies. In essence, boosting NAD+ levels triggers a shift in our cells that enhances survival, including boosting energy production and upregulating cellular repair.

Naturally, there’s a huge amount of interest in NMN supplements and with that, there are a number of different brands on the market. The best NMN supplements will contain the highest purity ingredients without any unnecessary additives. Some NMN supplements will also contain other well-known anti-aging ingredients to maximise the overall benefit.

We’ve put together a list of the best NMN supplements based on ingredient quality, dosage and value for money.

When it comes to choosing a top NMN supplement, there are only a few considerations that you need to be aware of.

The best NMN supplements will contain a minimum of 98% purity NMN.

The ideal NMN dose is not yet known and will be unique to every person. Research studies often use doses between 300 – 900mg and this is the range you’ll often see in the best available NMN brands

Always look for brands that manufacture NMN in a GMP certified (good manufacturing practice) facility. In addition, some brands will also send their product for 3rd party testing which double checks the purity and dose. You’ll also want to avoid any fillers or packing agents so that you only consume the ingredients you need.

Although NMN is arguably one of the best anti-aging molecules available, there are many other research-backed ingredients to be aware of. That’s why some supplements will combine NMN with other anti-aging ingredients such as Resveratrol, Fisetin, Spermidine, Quercetin and other antioxidants.

With this in mind, here is a list of some of the best NMN supplements around right now.

NMN Purity: 98%

NMN dose: 500mg


Other ingredients:

Price: $59.97

OMRE uses veggie capsules and avoids additives like magnesium stearate and silicon dioxide. Furthermore, their product is manufactured in the USA in a facility that’s FDA and GMP registered.

NMN Purity: 98%

NMN dose: 500mg


Other ingredients:

Price: $59.99

Toniiqs elixir blends NMN with Resveratrol and Trimethylglycine. Trimethylglycine is  naturally occurring methyl donor, that restores methionine homeostasis in cells.

They randomly batch test their products to guarantee quality and offer a 60 day money back guarantee.

NMN Purity: 98%

NMN dose: 500mg


Price: $84.95

Renue by science uses a powder-based liposome formula to enhance absorption. The claim is that this delivery method protects NMN from digestive enzymes. With this novel delivery system comes a premium price tag which may not be suitable to everyones budget. Nevertheless, it’s a top rated NMN supplement from a reputable brand.

NMN Purity: 99%

NMN dose: 500mg


Price: $58

ProHealth uses a patented NMN source from Uthever which claims over 99% purity. This supplement does not contain any additives like magnesium steararte. Instead, they use brown rice powder which is a natural alternative.

ProHelath sells a range of NMN forms such as lozenges, capsules and powders to suit all consumer needs.

NMN Purity: 98%

NMN dose: 250mg


Price: $49

Double woods is a brand that has been producing high quality supplements for many years now. They are a company with lots of experience and a strong reputation.

The capsules they use are Gelatin based so are not suitable for those who are vegetarian or vegan.

NMN is short for nicotinamide mononucleotide. It’s a micronutrient and derivative of vitamin B3 that we all produce in our cells and is also present in various foods such as avocado, broccoli and edamame.

In fact, vitamin B3 is converted into NMN (in several steps). That’s why people often ask if NMN and vitamin B3 are the same thing. But they are not. Vitamin B3 is just one of the building blocks required to make NMN.

In our cells, two NMN molecules are combined to for NAD+. Hence why taking NMN supplements boosts NAD+ levels.

And NAD+ is involved in many cellular processes, including energy metabolism and DNA repair. As we age, the levels of NAD+ in the body decrease, leading to a decline in these processes and potentially contributing to age-related diseases.

Over the last 20 years, several animal studies have shown that boosting NAD+ levels has a significant positive impact on the hallmarks of aging.

What are the hallmarks of aging?

The list can be long, but it all boils down to the following 4 factors which are the key hallmarks of aging to be aware of:

1 – Increased levels Inflammation

2 – Reduced insulin sensitiity

3 – Reduced mitochondrial function

4 – Gene instability and impaired DNA repair

There are many NAD+ boosting ingredients. But NMN is seen as the most powerful because it’s a direct precursor to NAD+.

So even though its not yet proven to have benefits in humans, there are high hopes for NMN’s potential.

A human clinical trial looked at excactly this question in 2022. The study involved 80 middle-aged healthy adults randomized for a 60-day clinical trial with once daily oral dosing of placebo, 300 mg, 600 mg, or 900 mg NMN.

They looked at the following things:

And the results were fascinatiing.  Here’s what they found after 60 days:

Interestingly, a significant benefit was seen even at a smaller dose of 300mg in most parameters. And a dose of 600mg had the biggest impact on physical performance.

It’s important to highlight that this was a small study of only 80 people. So a lot more research needs to be done. But the initial findings are very promising.

What’s the ideal NMN supplement dosage?

It’s not yet known what the ideal NMN supplement dose is. But going off the study mentioned above, it’s clear that even a smaller dose of 300mg has a significant benefit over placebo.

The best NMN supplements will include a dose of around 500mg which is in the middle of the range used in research studies.

And realistically, the ideal NMN dose is going to vary from person to person.

The most accurate way of finding out the best NMN dose for you is to test your blood parametrs and biological age. This is easier said than done and can be costly.

Alternatively, you could consider starting with a smaller dose and see how you respond.

As we’ve already alluded to, there are only a handful of studies in humans and most have looked at giving daily NMN over a period of up to 3-4 months.

In the studies so far, NMN starts to boost NAD+ levels in as little as a few weeks and certainly by 30 days.

How long this takes to translate into observable and measurable health benefits is as yet unknown.

The study we mentioned above reports improved walking distance and blood biomarkers of agining seen after 2 months.

Realistically, noticeable benefits will probably take a lot longer than this. As with all things health related, very little changes over night!

Harvard professor Dr David Sinclair and his colleagues recommend taking NMN supplements in the morning.

That’s because our cells naturally produce more NAD+ in the morning and levels decline by the time it’s evening.

So to match your cells biology, taking NMN supplements in the morning makes the most sense.

Unlike other supplements where absorption is often an issue, NMN quickly absorbed from the gut into blood circulation within 2–3 min and then into your cells within 15 min.

Some brands sell NMN in liposomal format which may enhance absorption even further. But even standard powdered or capsule NMN supplements achieve excellent absorption.

Getting a high enough amount of NMN from food sources is very difficult.

NMN supplements on the other hand contain anywhere between 300-1000mg of NMN.

That means an average avocado weighing 200g will contain around 2mg of NMN. You’d need to eat around 250 avocados to obtain 500mg of NMN.

So the best way to get enough NMN to make an impact is only through supplements. It’s not possible to achieve a high enough dose from your diet to impact NAD+ levels.

Before you begin your search, consider what you’d like your NMN supplement achieve. Do you want a specific NMN dose? Are you hoping to combine other anti-aging ingredients? What are your current barriers to health?  weight loss: an insatiable appetite, a lack of motivation in the gym, or something else?

Understanding your goals can help you look for NMN supplements with the appropriate benefits. It’s always important to remember that NMN supplements are not the magic elixir of youth and there are lots of other and arguably, more important factors to good health.

The best NMN products will not only contain high purity NMN, but also avoid the use of any artificial additives. When you’re purchasing NMN supplements, it’s not just the NMN itself you should be thinking of. Does it contain any fillers or additives like magnesium stearate? Is the capsule made from vegetable cellulose or animal based gelatin? Are there any other unexpected ingredients listed?

All of this matters when you want to differentiate the best NMN supplements. And it’s not easy to tell most of the time because this information is usually listed in small print on the back of the label.

NMN supplements can range in price from under $30 a bottle to over $100 a bottle. Most of the supplements above fall in a moderate price range of around $50 to $90 for a one-month supply.

Many companies also offer discounts for new customers or when you order in multi-packs.

NMN supplements are designed to be taken continuously. It is highly unlikely you’ll notice any difference within a few weeks, the same reason why won’t have a 6 pack after going to the gym for a month.

Look out for money-back guarantees which adds another layer of protection if you decide NMN isn’t right for you. The 4 best NMN brands we’ve picked all offer a no quibble money-back guarantee. Reputable brands will always back themselves and the quality of the products they sell.

NMN is an expensive ingredient. It’s not the same as your run of the mill B complex or vitamin C that you may purchase for cheap on Amazon. With this comes a premium price tag. You may come across NMN supplements that are very cheap, but always question the accuracy and quality of their product.

NMN is not a magic supplement that’s going to solve your health and longevity goals. There are several lifestyle factors that boost NAD+ levels naturally which you should consider alongside taking NMN supplements.

These include:

Intermittent fasting has gained popularity in recent years for its potential health benefits, including its possible impact on longevity. While the exact mechanisms are still being studied, here are some ways in which intermittent fasting may contribute to improved longevity:

If you do plan to start a fasting regimen, you must speak to your doctor first to make sure it is safe for you to do so. It is not suitable for some people and does not come without risks.

High-intensity exercise has been shown to have several positive effects on longevity. High intensity exercise can mean different things to different people. But in essence, it describes a form of exercise that involves bursts of activity, followed by short rest periods. So it can take any shape of form and be achieved with all forms of exercise. Here are some ways in which it may contribute to improved longevity:

Some scientis would argue that the best way to enhance longevity is to improve your sleep. There is now ample evidence to suggest that poor sleep is linked with a variety of negative health outcomes, inclduing premature death.

If you’re thinking of taking NMN supplements as part of your daily routine, you should also consider optimizing your sleep as a first step.

Simple things like avoiding screens after dark, drinking less caffeine and removing distractions from your bedroom can have a big impact on your sleep quality. Avoiding alcohol before bed is also very important as it blocks your brain from entering REM sleep.

There’s no point of investing in NMN supplements if you don’t also invest in improving your diet. The best diet for longevity is a topic of ongoing research, and there is no single “one-size-fits-all” approach. However, several dietary patterns have been associated with improved longevity and overall health. Here are some dietary principles that are often recommended for promoting longevity:

There is limited research on the safety and side effects of NMN supplements, but some studies have reported mild side effects. These side effects include:

It’s important to note that these side effects are generally mild and temporary, and don’t occur in most people who take NMN supplements.

However, it’s always advisable to talk to a healthcare professional before taking any new supplement, especially if you have any underlying health conditions or are taking medications. Additionally, it’s essential to follow the recommended dosage guidelines and not start off with a very high dose, as excessive intake may increase the risk of adverse effects.

While there is some promising research on the benefits of NMN, there are also potential downsides to its use. Some of these downsides include:

Here are some of the most common questions people have about NMN supplements

NR (nicotinamide riboside) is the precursor the NMN. So its one step further away from NAD+.

While both NMN and NR have been studied for their potential health benefits, there is currently no clear evidence to suggest that one is definitively better than the other.

Some studies suggest that NMN may be more effective than NR at increasing NAD+ levels in certain tissues and organs, such as the liver and muscle tissue. Other studies have found that NR may be more effective than NMN at increasing NAD+ levels in the brain and peripheral nervous system.

However, these findings are still preliminary, and more research is needed to fully understand the differences between NMN and NR and their effects on NAD+ metabolism and health.

Unlike comparing NMN to NR, it’s more difficult to compare NMN to Resveratol because they are very different compounds.

Resveratrol is a polyphenol that is found in certain foods such as grapes, peanuts, and red wine. In essence, it’s a plant-based antioxidant.

While NMN’s only function is to boost NAD+ levels. Resveratrol boosts NAD+ in addition to having several other benefits such as antioxidation, sirtuin activation and reducing inflammation.

That’s why some of the best NMN brands also include Resveratrol to provide an all-round potent anti-aging supplement.

Does NMN make you look younger?

A few studies have investigated the effects of NMN supplementation on skin aging in mice. One study found that NMN supplementation helped to improve skin barrier function and reduce wrinkle formation in mice. Another study found that NMN supplementation helped to improve skin elasticity and reduce collagen degradation in mice.

However, it’s important to note that these studies were conducted in mice, and more research is needed to fully understand the effects of NMN supplementation on skin aging in humans. Additionally, there are many factors that contribute to the aging process, and it’s unlikely that NMN supplementation alone can completely reverse the effects of aging or make a person look younger.

Harvard professor Dr Sinclair is arguably one of the best-known advocates of NMN supplements. His research has paved the way into identifying NMN as one of the best supplements to support healthy aging. He openly states that he takes 1000mg of NMN with 1000mg of Resveratrol every day.

But he doesn’t say which specific NMN brand he uses. In reality, the specific NMN supplement that David Sinclair takes is not so important. Ultimately, all that matters is whether the NMN purity is high and from a reputable manufacturer.

If you practice intermittent fasting, you’ll want to know if you can take NMN on an empty stomach.

The short answer is, yes you can. NMN is absorbed well through the gut, even on an empty stomach.

Some people may experience some abdominal discomfort when taking NMN on an empty stomach, in which case taking it with food will mitigate this problem. But the vast majority of people will have no issues with taking NMN on an empty stomach.

There is no specific age at which it is recommended to start taking NMN (nicotinamide mononucleotide) supplements, as the effects of aging and the rate at which NAD+ levels decline can vary among individuals.

Some studies have shown that NAD+ levels begin to decline as early as in our 20s, while others have found that NAD+ levels decline more rapidly after the age of 50. Therefore, some people may choose to start taking NMN supplements earlier in life as a preventative measure, while others may start later when they begin to notice age-related changes.

So there you have it, that wraps up our review of the best NMN supplements on the market.

We’ve walked you through some of the key things to look our for when buying NMN supplements and have picked out a handful of the top NMN brands on the market right now.

But there are other great options on the market so long as you make sure to look out for a reputable brand that contains high purity NMN thats manufactuerd in a GMP certified facility without any additives.

This is sponsored content. M&F is not endorsing the websites or products listed in this article.


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